Streptococcus Immunogen Arthritis - Bacterial Antigen made from 2000 million per cc. hemolytic and non-hemolytic Streptococci isolated from rheumatic cases

According to 1940 product literature supplied by Parke, Davis & Company:

"The name 'I'mmunogen' identifies the specific antigenic substances obtained from he surface or ectoplasm of bacterial cells. This type of antigen has been designated as 'ecto-antigen'"'

"The power of Immunogens to stimulate the production of immune bodies is high and compares favorably with that of other specific antigen used for similar purposes. / Immunogens are indicated when stimulation of the natural defense mechanism of immunity is desirable in the prophylaxis or treatment of acute and chronic infections."

"Immunogens are administered by injection. Intracutaneous, subcutaneous, and intramuscular routes are used most commonly; Immunogens may be given intravenously in small doses if desired. Subcutaneous injection is usually followed by more local reaction than intramuscular."

"Clinical Indications: Immunogens are applicable in the same class of cases as bacterial vaccines - for specific immunization. Both are antigenic - capable of stimulating the production of antibodies; and both are specific, the bacteriology of the infection under treatment pointing to the proper vaccine or Immunogen to be used. / The advantage of Immunogens lies, not in greater specificity, but in greater freedom from nonessential and possibly irritating elements. They contain comparatively little protein. Therefore, they can often be used with good effect in acute infections where vaccines would be less desirable."

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